The process in which various drugs are brought together, to manufacture a medicinal product is known as Drug formulation. The formulation process inspects and then gives importance to factors such as the pH, polymorphism, solubility and particle size as all these can affect the actions of the drug. The drug formulation process needs to be continued until it reaches the last stages of clinical trials so that it can be used in the open...
Posts Tagged ‘Formulation’
Posted in 
Tags: 
The Effect of Formulation on the Quality of Film Coated Tablets
octobre 20th, 2011 
Sebasti3n By: Marina Levina and Charles R. Cunningham Tablets are by far the most popular dosage form when administering drugs to patients, and a large proportion of the tablets produced around the world are film coated. Coating is applied for a variety of reasons such as aesthetic appearance; identification and branding; taste or odor masking; enhanced mechanical strength; and protection from moisture, light and/or air. With the current awareness of health, safety and environmental problems, aqueous...
Outsourcing Drug Formulation Development
octobre 20th, 2011 Sebasti3n With the increase in the demand for new and more effective drug medications, a number of companies have emerged to provide third-party services to the pharmaceutical industry in an effort to make the complex process of drug formulation development faster and easier. Most pharmaceutical companies have resorted to outsourcing such important and difficult processes to qualified and expert formulators. The process is done to determine the best form that a certain drug should take, whether...
Preformulation and Formulation Development
octobre 20th, 2011 Sebasti3n Optimizing Conformational Stability and Biological Activity Maintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate among various buffer, pH, ionic strength, and excipient...
